Mar 23, Arrabidaea chica (HBK) Verlot, Bignoniaceae, is a scrambling shrub native to tropical America, more particularly in the Amazon basin where it. Arrabidaea chica (Humb. & Bonpl.) Verl. Show All Show Tabs cricketvine. General Information. Symbol: ARCH5. Group: Dicot. Family: Bignoniaceae. Duration. A new flavone, 6,7,3′,4′-tetrahydroxymethoxyflavone, named carajuflavone, was isolated from the leaves of the Brazilian plant Arrabidaea chica f. cuprea.

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CL and VL represent a serious public health problem in 98 countries and 3 territories on 5 continents arabidaea the disease can be found. The B2 fraction from the A. Another report showed that the hidroalcoholic extract of A. However, most of these drugs are expensive, present toxic effects, and are able to induce parasite resistance [ 5 ].

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Zimmermann for her technical assistance. Chemical investigations have been carried out since the beginning of this century to determine the composition arrabiidaea the A.

The anti-inflammatory effect was already demonstrated in vivo Oliveira et al. In this study we evaluated mononuclear cells in the blood of five animals per group.

Amphotericin B was purchased from Fontoura-Wyeth, Brazil. It is the second largest cause of death in the world.

Whether cytokines may be involved in this process is currently under study in this laboratory. Analysis was performed at room temperature.

Peritoneal mouse macrophages were obtained as described above. Inhibitory activity of the B2 fraction obtained from the A. Column chromatographic product was purchased from Merck Darmstadt, Germany. It is possible that the antitumor effect of A.


During the last decade, natural antioxidants, particularly phenolics, have been under very close scrutiny as potential therapeutic agents against a wide range of ailments including cancer, inflammatory diseases and also aging. Phenolics as potential antioxidant therapeutic agents: The authors thank Luciana T. Apparently the same occurs here, suggesting that other nonspecific inflammatory mechanism might be relevant in tumor resistance.

The photomicrographs were obtained using an electron microscope Jeol JEM Phytochemical analysis Chemical tests to detect the main classes of secondary metabolites were carried out in aqueous extract AE using classical specific color reactions Matos, Peptidase gelatinase activity was analyzed through the protocol adapted from Cedrola et al.

Measures of mice paws showed a continuous tumor growth in all experimental groups.

Arrabidaea chica

Hence, there is a great potential for the development of anticancer drugs from the essentially untapped reservoir of the plant kingdom. Besides, after treatment with However, the ethanol extract EE caused a significant increase in neutrophils count Table 3.

Cancer is a disease of misguided cells that have high potential of excess proliferation without apparent relation to the physiological demand of the process. There were groups of large and oval cells with abundant vacuolated faintly basophilic cytoplasm with indistinct chiac. Fatty acids and sterols probably are the main components involved in the antileishmanial activity, but further investigation will be necessary in order to evaluate the isolated compounds.


We do not discard the possibility that neutrophils exert cytotoxic effects against EAC cells contributing to the inhibition of tumor growth. The cell suspension was kept on ice for 5 min and washed twice in RPMI Transmission electron microscopy of L.

BioMed Research International

The protocols, antibodies and reagents employed were as per the manufacturer’s recommendations Sigma. Note the rupture of the mitochondrion membrane arrowhead in c. Please share your Comments. Ramos Barbosa, and J. All groups presented extensive areas of necrosis scattered trough tumor tissue with discrete areas of hemorrhage.

arrabidaea chica leaf/stem extract

The time of tumor development 12 days was probably not sufficient to cause exhaustion of the bone marrow. Veterinary hematology and clinical chemistry. Arrabidaea chica, Bignoniaceae, flavonols, Ehrlich tumor, antitumor activity. The retention time of kaempferol was found to be Mitochondrion seems to be a common target for several natural products, crude extracts, or isolated compounds, as has been reported by several researchers [ 1022 — 24 ].

Here, the B2 fraction demonstrated significant peptidase inhibition when tested on cellular lysates of Leishmania Figure 1. More recently, the action mechanism of some fatty acids has been related to topoisomerase IB inhibition as demonstrated by Carballeira et al. Telles II ; Vany P.